EFFECTS OF TOPICAL OXYBUTYNIN CHLORIDE IN WOMEN WITH DYSFUNCTIONAL BLADDERS - RESULTS OF A DOUBLE-BLIND PLACEBO-CONTROLLED STUDY

Detrusor instability is the second most common cause of femal urinary incontinence. Oxybutynin chloride anticholinergic action with direct m uscle-relaxant properties. 39 women with persistent-urgein-continence participated in a pilot study of intravesical oxybutynin application. Patients received either 20 mg oxybutynin or placebo as 40 ml sterile sodium chloride solution administered intravesically over a period of 10 days. Urodynamic assessment as well as micturition protocols were p erformed before and after treatment. The intravesical oxybutynin-appli cation was significantly better than the placebo application concernin g reduction of pollakisuria and nycturia. Oxybutynin also increased bl adder capacity more than in the placebo-treated group (p < 0.01) and p rovided an improvement of bladder compliance (p < 0.05). No local or s ystemic side effects were observed which would have immediately termin ated the oxybutynin treatment.