HUMAN PROTHYMOSIN-ALPHA INHIBITS DIVISION OF YEAST SACCHAROMYCES-CEREVISIAE CELLS, WHILE ITS MUTANT LACKING NUCLEAR-LOCALIZATION SIGNAL DOES NOT

Authors
PAVLOV N EVSTAFIEVA A RUBTSOV Y VARTAPETIAN A
Citation
N. Pavlov et al., HUMAN PROTHYMOSIN-ALPHA INHIBITS DIVISION OF YEAST SACCHAROMYCES-CEREVISIAE CELLS, WHILE ITS MUTANT LACKING NUCLEAR-LOCALIZATION SIGNAL DOES NOT, FEBS letters, 366(1), 1995, pp. 43-45
Citations number
14
Categorie Soggetti
Biophysics,Biology
Journal title
FEBS letters → ACNP
ISSN journal
00145793
Volume
366
Issue
1
Year of publication
1995
Pages
43 - 45
Database
ISI
SICI code
0014-5793(1995)366:1<43:HPIDOY>2.0.ZU;2-P
Abstract
Effect of human prothymosin alpha and its mutant overproduced in S. ce revisiae on yeast cell division was studied. Wild-type prothymosin alp ha appeared to block division of yeast cells. Its inhibitory action co uld be abolished by deletion of the last nine carboxy-terminal amino a cids of prothymosin alpha containing nuclear localization signal, thus pointing to the nucleus as a compartment, where prothymosin alpha per forms its action,