N. Pavlov et al., HUMAN PROTHYMOSIN-ALPHA INHIBITS DIVISION OF YEAST SACCHAROMYCES-CEREVISIAE CELLS, WHILE ITS MUTANT LACKING NUCLEAR-LOCALIZATION SIGNAL DOES NOT, FEBS letters, 366(1), 1995, pp. 43-45
Effect of human prothymosin alpha and its mutant overproduced in S. ce
revisiae on yeast cell division was studied. Wild-type prothymosin alp
ha appeared to block division of yeast cells. Its inhibitory action co
uld be abolished by deletion of the last nine carboxy-terminal amino a
cids of prothymosin alpha containing nuclear localization signal, thus
pointing to the nucleus as a compartment, where prothymosin alpha per
forms its action,