INFLUENCE OF MOLECULAR-STRUCTURE ON THE DEGRADATION MECHANISM OF DEGRADABLE POLYMERS - IN-VITRO DEGRADATION OF POLY(TRIMETHYLENE CARBONATE), POLY(TRIMETHYLENE CARBONATE-CO-CAPROLACTONE), AND POLY(ADIPIC ANHYDRIDE)

Relationships between molecular structure and the degradation mechanis m of degradable polymers are of special interest for temporary medical applications. The in vitro degradation study of three aliphatic polym ers-poly(trimethylene carbonate) (PTMC), poly(trimethylene carbonate-c o-caprolactone) (PTMC-PCL), and poly(adipic anhydride) (PAA)-revealed that these polymers exhibit degradation times from several years (PTMC ) to 1 day (PAA). PTMC degraded unexpectedly slow, accompanied by very small changes in weight loss, molecular weight (SEC), and in morpholo gy (DSC, SEM). The degradation was independent of initial molecular we ight, ionic strength of the water solution, temperature, and shaking m otions. The copolymer PTMC-PCL showed a higher degradation rate compar ed to PTMC, with preferential degradation of amorphous parts leading t o an increase in % crystallinity. The surprisingly rapid degradation o f PAA showed characteristics typical for a surface-like eroding system in contrast to PTMC and PTMC-PCL. The degradation products correspond ed to the repeating unit of the polymers. The hydrolysis rate increase s in the order carbonate, ester, anhydride, and by combining different molecular structures we achieve specific degradation behavior. A chan ge in hydrolysis rate of the labile bond is predicted by altering the electronegativity of groups near the carbonyl-oxygen region. (C) 1995 John Wiley and Sons, Inc.