IN-VITRO ACTIVITY OF OXAZOLIDINONES AGAINST MYCOBACTERIUM-AVIUM COMPLEX

Authors
PETERS J KONDO KL LEE RK LIN CK INDERLIED CB
Citation
J. Peters et al., IN-VITRO ACTIVITY OF OXAZOLIDINONES AGAINST MYCOBACTERIUM-AVIUM COMPLEX, Journal of antimicrobial chemotherapy, 35(5), 1995, pp. 675-679
Citations number
10
Categorie Soggetti
Microbiology,"Pharmacology & Pharmacy
Journal title
Journal of antimicrobial chemotherapy → ACNP
ISSN journal
03057453
Volume
35
Issue
5
Year of publication
1995
Pages
675 - 679
Database
ISI
SICI code
0305-7453(1995)35:5<675:IAOOAM>2.0.ZU;2-8
Abstract
Options for treating disseminated Mycobacterium avium complex (MAC) di sease have improved. However, efficacy is not always certain, resistan ce is common and rapidly bactericidal agents would improve efficacy an d prevent resistance. Certain oxazolidinones were tested against MAC s trains and inhibited growth at expected serum concentrations or lower. Activity correlated with hydrophobicity and one agent was bactericida l at concentrations two to five times greater than the MIC.