TOXICITY OF COTORAN (FLUOMETURON) IN DESERT SHEEP

Twelve of fifteen 6-9-mo-old clinically healthy Desert sheep were give n single or repeated daily doses of 25 to 4000 mg cotoran/kg by drench . Cotoran poisoning was characterized by grinding of the teeth, rumina l tympany, mydriasis, dyspnea, staggering, paresis of the hind and for elimbs, and recumbency. Lesions were widespread congestion and hemorrh age, hepatic fatty change, catarrhal enteritis and degeneration of the epithelial cells of the renal proximal convoluted tubules. These were accompanied by significant increases in the activities of GOT, LDH an d GGT and decreases in serum total protein and calcium.