A case of overdosage with closantel, a salicynalide derivative, in a d
og is described. The dog received 6 times the recommended dosage. Clos
antel induced optic neuritis, retinal degeneration, partial deafness,
hepatotoxicosis and myopathy. Only the blindness was irreversible. The
therapy included albumin administration to reduce the acute toxicity
of closantel.