Intrauterine cocaine exposure has been associated with multiple transi
ent and permanent neurologic sequelae. Although dystonic reactions hav
e been reported in cocaine users, infantile dystonia following intraut
erine exposure has not. We describe 4 infants testing positive for coc
aine metabolite at birth with subsequent transient dystonic reactions,
beginning at 3 hours to 3 months of age and persisting for several mo
nths.