Two cases of amyloid goitre presented as an enlarged thyroid mass with
cystic components, Solid parts of the goitre showed high attenuation
on computed tomography (CT) and moderate hypointensity on T1 and T2-we
ighted images. Fine needle aspiration was negative for amyloid, but pa
thological studies of surgical specimens demonstrated amyloid infiltra
tion of the thyroid interstitium and regressive colloid cysts. In a pa
tient at risk for systemic amyloidosis, thyroid enlargement with a cys
tic component suggests amyloid goitre. In this case, needle biopsies s
hould be directed to solid areas of the mass because amyloid material
may not be present in the cysts.