STRATEGIES FOR THE GENE-THERAPY OF MELANO MA

Citation
R. Dummer et al., STRATEGIES FOR THE GENE-THERAPY OF MELANO MA, Hautarzt, 46(5), 1995, pp. 305-308
Citations number
32
Categorie Soggetti
Dermatology & Venereal Diseases
Journal title
ISSN journal
00178470
Volume
46
Issue
5
Year of publication
1995
Pages
305 - 308
Database
ISI
SICI code
0017-8470(1995)46:5<305:SFTGOM>2.0.ZU;2-4
Abstract
Active unspecific immunotherapy in an adjuvant or palliative setting h as been shown to enhance survival in melanoma patients, and gene thera py now offers new perspectives for active specific immunotherapy. Gene therapy includes the transfer of genetic material performed by either viral or non-viral methods and in vivo or ex vivo. For melanoma the f ollowing approaches are suggested: vaccination with tumour-specific, H LA-associated antigens using peptides or 'naked DNA', vaccination with melanoma cells transfected with cytokine genes or B7, adoptive immuno therapy with specific T-lymphocytes tumour-infiltrating lymphocytes, o r transfection of tumour cells with a tumour suppressor gene whose dys function plays a crucial role in melanoma.