LOCAL ANTISEPSIS AND WOUND-HEALING - IN-V ITRO AND IN-VIVO EXAMINATION

Wound healing represents a dynamic process of increasing scientific in terest, especially with the detection of the different growth factors. Economic aspects are also of importance in the investigation of subst ances used for wound healing. In Germany 25% of all patients (ca. 1 mi llion) with severe chronic venous insufficiency have crural ulcers. Th e influence of bacterial infection of crural ulcers is controversial. There is no doubt that the quantity of bacteria is of importance. Loca l antibiotic treatment is difficult, as most of the substances used ar e known to inhibit wound healing. In vivo and in vitro investigations showed, that chiniofon-containing antiseptic has a bacteriostatic func tion. Additionally it was shown, using cultures of fibroblasts, that c hiniofon-containing antiseptic does not inhibit the growth of fibrobla sts, whereas PVP-iodine solution, a widely used antiseptic, clearly re duces the growth of fibroblasts. The good clinical results in the trea tment of acute and chronic radiation damage indicate that chiniofon-co ntaining antiseptic may have antiflammatory activity.