DICARBANONABORATES - NEW INHIBITORS OF MITOCHONDRIAL L-GLYCEROL-3-PHOSPHATE DEHYDROGENASE

Citation
Z. Drahota et al., DICARBANONABORATES - NEW INHIBITORS OF MITOCHONDRIAL L-GLYCEROL-3-PHOSPHATE DEHYDROGENASE, Biochemical and biophysical research communications, 210(3), 1995, pp. 760-765
Citations number
25
Categorie Soggetti
Biology,Biophysics
ISSN journal
0006291X
Volume
210
Issue
3
Year of publication
1995
Pages
760 - 765
Database
ISI
SICI code
0006-291X(1995)210:3<760:D-NIOM>2.0.ZU;2-B
Abstract
The inhibitory effect of mercapto- and chloro-dicarbanonaborates on mi tochondrial, FAD-linked, L-glycerol-3-phosphate dehydrogenase activity was tested. The mercaptodicarbanonaborate was found to be a more pote nt inhibitor than the chloro derivative. The K-i of mercapto- and chlo rodicarbanonaborates were 0.8 M and 480 M, respectively. Whereas the m ercaptodicarbanonaborate inhibited the enzyme activity competitively, the inhibitory effect of chloro derivative was noncompetitive. The inh ibitory effect of mercaptodicarbanonaborate was completely prevented b y addition of bovine serum albumin. (C) Academic Press, Inc.