ERYTHROMYCIN SUPPRESSES INTERLEUKIN-6 EXPRESSION BY HUMAN BRONCHIAL EPITHELIAL-CELLS - A POTENTIAL MECHANISM OF ITS ANTIINFLAMMATORY ACTION

Authors
TAKIZAWA H DESAKI M OHTOSHI T KIKUTANI T OKAZAKI H SATO M AKIYAMA N SHOJI S HIRAMATSU K ITO K
Citation
H. Takizawa et al., ERYTHROMYCIN SUPPRESSES INTERLEUKIN-6 EXPRESSION BY HUMAN BRONCHIAL EPITHELIAL-CELLS - A POTENTIAL MECHANISM OF ITS ANTIINFLAMMATORY ACTION, Biochemical and biophysical research communications, 210(3), 1995, pp. 781-786
Citations number
20
Categorie Soggetti
Biology,Biophysics
Journal title
Biochemical and biophysical research communications → ACNP
ISSN journal
0006291X
Volume
210
Issue
3
Year of publication
1995
Pages
781 - 786
Database
ISI
SICI code
0006-291X(1995)210:3<781:ESIEBH>2.0.ZU;2-Z
Abstract
We evaluated the effects of several antibiotics on IL-6 expression by human bronchial epithelial cells, potent sources of this proinflammato ry tory cytokine important in airway inflammation. Among those tested, erythromycin (EM) and clarithromycin (CAM) uniquely suppressed mRNA l evels as well as the release of IL-6 at the therapeutic and non-cytoto xic concentration (10(-6)M). Our findings suggested that these macroli de antibiotics had suppressive effect on cytokine expression in human cells, and this new mode of action may have relevance to their clinica l effectiveness in airway inflammatory diseases. (C) 1995 Academic Pre ss, Inc.