SEPSIS IN CHILDREN WITH HUMAN-IMMUNODEFICIENCY-VIRUS INFECTION

The aims of this retrospective study were to review the frequency and patterns of bacterial sepsis in children infected with human immunodef iciency virus, The charts of 233 human immunodeficiency virus-infected children cared for during a 10-year period in 4 tertiary hospitals in Madrid were reviewed, There were 43 episodes of sepsis in 31 (13%) ch ildren, Twenty of them had acquired immunodeficiency syndrome, 10 were class P2A and 1 was class P1B. The most common organisms recovered we re: nontyphoidal Salmonella, 10 cases (23%); Streptococcus pneumoniae, 9 cases (21%); Staphylococcus epidermidis, 6 cases (14%); Escherichia coli, 5 cases (12%); Enterococcus faecalis, 4 cases (9%); Campylobact er jejuni, 2 cases (5%). In 28 episodes of bacteremia there were other sites of associated infection: pneumonia, 6 cases; urinary tract infe ction (UTI), 5 cases; gastrointestinal disease, 4 cases; catheter-rela ted bacteremia, 12 cases, Eight patients had more than 1 episode of ba cteremia, The rate of complications was high: 6 children had septic sh ock; and 2 of them developed disseminated intravascular coagulation, T here was 1 death directly related to sepsis,