ROLE OF PROTEASE INHIBITION IN MYOCARDIAL PRESERVATION FOLLOWING ISCHEMIA AND REPERFUSION

Authors
GUREVITCH J PAZ Y BARAK J MATSA M KRAMER A PEVNI D HOCHHAUSER E YAKIREVICH V
Citation
J. Gurevitch et al., ROLE OF PROTEASE INHIBITION IN MYOCARDIAL PRESERVATION FOLLOWING ISCHEMIA AND REPERFUSION, Journal of Cardiovascular Surgery, 35(6), 1994, pp. 95-98
Citations number
NO
Categorie Soggetti
Cardiac & Cardiovascular System",Surgery
Journal title
Journal of Cardiovascular Surgery → ACNP
ISSN journal
00219509
Volume
35
Issue
6
Year of publication
1994
Supplement
1
Pages
95 - 98
Database
ISI
SICI code
0021-9509(1994)35:6<95:ROPIIM>2.0.ZU;2-2
Abstract
Aprotinin, a naturally occurring protease inhibitor, in concentrations of 10(6) KIU/L was found to have no effect on myocardial performance in normally perfused isolated rat hearts, before ischemia. Given durin g the preischemic period, the drug had a significant protective effect on the reperfused hearts, following cardioplegic ischemia: better con tractility upon reperfusion (p < 0.011), faster decline of the ischemi c contracture, higher coronary flow (p < 0,025), lower AV-difference ( p < 0.05), and lower CPK levels (p < 0.01).