THE USE OF HIGH-DOSES OF APROTININ TO DECREASE BLOOD-LOSS IN AORTOCORONARY BYPASS-SURGERY

There were examined 100 patients who had been operated in extracorpore al circulation for ischemic heart disease. In the Ist group (50 patien ts), each patient intraoperatively received 6,000,000 KIE of aprotinin ; in the 2nd group (50 patients) placebo. Both groups were similar as for the age, duration of extracorporeal circulation, and myocardium an oxia. The total intraoperative blood loss was higher in 2nd group, 638 +/- 5 ml and 952.4 +/- 15.5 ml p < 0.05 correspondingly. The rate of cases without the intraoperative use of donor blood was 42% in group 1 and 18% in group 2. The postoperative blood loss was significantly lo wer with the use of aprotinin, 392 +/- 6.6 ml and 689.7 +/- 9.6 ml, p < 0.05 correspondingly; and in that the Hb concentration in the draina ge blood was higher in group 2: 31.3 +/- 0.5 g and 73.1 +/- 2.2 g, p < 0.05. In group 1 22% of the patients received donor blood in the earl y postoperative period, and group 2 twice as many - 56%. Thus prolonge d intraoperative use of large aprotinin dosages in aortocoronary by-pa ss surgery is an effective means for stabilization of homeostasis, and it allows to reduce intra- and postoperative blood loss and diminishe s the requirements in donor blood.