THE MITRAL-VALVE REPLACEMENT BY THE NEW-TYPE BIOPROSTHESES (FEATURES OF DESIGN AND LONG-TERM RESULTS)

Citation
Sl. Dzemeshkevich et al., THE MITRAL-VALVE REPLACEMENT BY THE NEW-TYPE BIOPROSTHESES (FEATURES OF DESIGN AND LONG-TERM RESULTS), Journal of Cardiovascular Surgery, 35(6), 1994, pp. 189-191
Citations number
NO
Categorie Soggetti
Cardiac & Cardiovascular System",Surgery
ISSN journal
00219509
Volume
35
Issue
6
Year of publication
1994
Supplement
1
Pages
189 - 191
Database
ISI
SICI code
0021-9509(1994)35:6<189:TMRBTN>2.0.ZU;2-X
Abstract
The BAKS bioprostheses were created in our centre and they have the fo llowing features: (1) to reduce immunogenicity they underwent a combin ed fermentochemical treatment which resulted in the native xenovalve c onsisting of collagen and elastic fibres only; (2) in cutting out the valve the natural aortic sinuses were preserved; and (3) the xenovalve was fixed on a functional frame of an original design. From 1979, BAK S have been implanted in 243 patients with the isolated mitral valve r eumatic injury. The patients age varied from 11 to 59 years; 91 patien ts (37.5%) were under 35 years. The 12-year survival rate (without hos pital lethality) was 65.5 +/- 5.3%. The most serious longterm complica tions were: infectious endocarditis (3.14 patients/years); spontaneous degeneration of bioprosthetic cusps (2.24% patients/years); thromboem bolism (0.6% patients/years). The morphological examination of biopros theses removed in reoperations from 10 days to 10 years after implanta tion was performed in 51 cases. Most often, collagen degeneration occu rred in patients under 35. The pathologic structural changes originate d because of the localized saturation of bioprosthetic cusps with the recipient plasma proteins, gradual disintegration of collagen fibres, and further calcification of that area. The indications to the mitral valve replacement by BAKS were: the left atrium thrombosis, thromboemb olytic syndrome, contraindications to anticoagulation therapy, and the age over 35 years.