EVALUATION OF A NEW PRESERVATION SOLUTION - CELSIOR IN THE ISOLATED RAT LUNG

Background: We compared Celsior solution, a new and original extracell ular preservation solution, with blood-based Wallwork's solution. Meth ods: In two groups of isolated rat lungs submitted to 4 hours of cold ischemia, pulmonary arterial and venous resistances, coefficient of fi ltration, and wet-to-dry lung weight ratio were determined at baseline and after 90 minutes of reperfusion. Results: After ischemia-reperfus ion, percentage of increases above the respective baseline coefficient of filtration values were 93% +/- 7% in the Wallwork group and 7% +/- 3% in the Celsior group (p < 0.001 versus Wallwork's solution). Concl usions: These results show that Celsior consistently prevented the isc hemia-reperfusion-induced increase in pulmonary microvascular permeabi lity as compared with Wallwork's solution.