ENANTIOSELECTIVE SEPARATIONS BY CAPILLARY GAS-CHROMATOGRAPHY ON DERIVATIZED CYCLODEXTRINS .4. ENANTIOSELECTIVE INTERACTION-MODEL OF 2,2-DIALKYL-4-ALKOXYCARBONYL-1,3-DIOXOLANE DERIVATIVES ON SOME SUBSTITUTED CYCLODEXTRINS

An evaluation of the effects of differently derivatized cyclodextrins and analyte geometry for a series of 2,2-dialkyl-4-alkoxycarbonyl-1,3- dioxolane derivatives on enantioselectivity has been performed. It was shown that changes in the cyclodextrin cavity size, caused by either the choice of type (alpha-, beta- or gamma-cyclodextrin) or substituti on pattern, strongly affect the selectivity of the chiral separation o f the substituted dioxolanes. The geometry of the analyte also appears to be very important to the selectivity. A model of the inclusion com plex is proposed.