INVOLVEMENT OF THE 4Q21 REGION IN HUMAN-MALIGNANT MELANOMAS - CYTOGENETIC AND IMMUNOCYTOCHEMICAL CHARACTERIZATION OF 3 PRIMARY-CELL CULTURES

Authors
GRAMMATICO P ROCCELLA M CATRICALA C ROCCELLA F BUCHER S MORDENTI C AMANTEA A DIROSA C DELPORTO G
Citation
P. Grammatico et al., INVOLVEMENT OF THE 4Q21 REGION IN HUMAN-MALIGNANT MELANOMAS - CYTOGENETIC AND IMMUNOCYTOCHEMICAL CHARACTERIZATION OF 3 PRIMARY-CELL CULTURES, World journal of surgery, 19(3), 1995, pp. 350-351
Citations number
3
Categorie Soggetti
Surgery
Journal title
World journal of surgery → ACNP
ISSN journal
03642313
Volume
19
Issue
3
Year of publication
1995
Pages
350 - 351
Database
ISI
SICI code
0364-2313(1995)19:3<350:IOT4RI>2.0.ZU;2-M
Abstract
The GRO1 oncogene (melanoma growth-stimulating activity alpha) has bee n localized in region 4q21, The involvement of this chromosomal region in clonal aberrations found in primary melanoma cell cultures could h ave an important role in the etiology and pathogenesis of this tumor. We characterized three primary cell cultures obtained from different p atients, each of which showed clonal chromosomal aberrations involving the 4q21 region.