R. Zabielski et al., INTRADUODENAL CHOLECYSTOKININ-OCTAPEPTIDE (CCK-8) CAN STIMULATE PANCREATIC-SECRETION IN THE CALF, International journal of pancreatology, 17(3), 1995, pp. 271-278
The effect of CCK-8 administered into the duodenal lumen and into the
systemic blood on pancreatic secretion and duodenal migrating myoelect
ric complex (MMC) was studied in four calves. Simultaneous MMC recordi
ngs and collections of pancreatic juice were performed on valves that
had been fasted overnight. Intraduodenal (0, 100, and 300 pmol/kg body
wt) and intravenous (0, 30, and 100/pmol kg) infusions of CCK-8 were
made for 5 min during the no spiking activity (NSA) phase of duodenal
MMC associated with a nadir of periodic pancreatic secretion. CCK-8 wa
s also administered during continuous atropine infusion (5 mu g/kg/min
). Both intraduodenal and intravenous infusions of CCK-8 resulted in m
arked pancreatic responses in juice outflow, bicarbonate output, and p
rotein output. Atropine decreased pancreatic response (protein output)
to intravenous CCK-8 and markedly inhibited the response (juice flow,
bicarbonate, and protein output) to intraduodenal CCK-8. Infusions of
CCK-8 did not affect the duration of MMC in the duodenum. Plasma CCK
increased significantly after intravenous infusion, but remained uncha
nged after intraduodenal infusion. In conclusion, CCK-8 can stimulate
pancreatic secretion from the duodenal lumen, possibly via a cholinerg
ic mechanism in the calf.