INFLUENCE OF CHIRAL CARVONES ON SELECTIVITY OF PURE LIPASE-B FROM CANDIDA-ANTARCTICA

Authors
ARROYO M SINISTERRA JV
Citation
M. Arroyo et Jv. Sinisterra, INFLUENCE OF CHIRAL CARVONES ON SELECTIVITY OF PURE LIPASE-B FROM CANDIDA-ANTARCTICA, Biotechnology letters, 17(5), 1995, pp. 525-530
Citations number
10
Categorie Soggetti
Biothechnology & Applied Migrobiology
Journal title
Biotechnology letters → ACNP
ISSN journal
01415492
Volume
17
Issue
5
Year of publication
1995
Pages
525 - 530
Database
ISI
SICI code
0141-5492(1995)17:5<525:IOCCOS>2.0.ZU;2-B
Abstract
In the esterification reaction in non-aqueous media lipase-B from Cand ida antarctica is stereoselective towards the R-isomer of ketoprofen i n an achiral solvent such as isobutyl methyl ketone and in S(+) carvon e. On the contrary, S(+) ketroprofen is esterified quicker in R(-) car vone. In addition, the esterification yield changes depending on the s tereochemistry of the carvone used as solvent. The formation of dister omeric complexes (chiral solvent + chiral substrates) may explain this finding.