G. Keck et Pm. Borne, ANTIMICROBIAL CHEMOTHERAPY - NEW CONSIDER ATIONS AND THEIR APPLICATIONS TO VETERINARY-MEDICINE, Revue de Medecine Veterinaire, 146(5), 1995, pp. 309-320
Relations between pharmacokinetics, antimicrobial activity, and distri
bution and maintenance should be studied in order to specify most effe
ctive posology schemes. Some antimicrobials are concentration-dependen
t : their bactericidal speed increases with concentration. Others are
time-dependent : their bactericidal activity reaches its maximum level
when MIC is obtained, and is then directly related to exposure time.
The post-antibiotic effect depends on the antimicrobial and the pathog
en considered, and can be measured in experimental models. Practical c
onsequences for antimicrobial prescribing are currently discussed, esp
ecially for bactericidal antimicrobials and taking into account toxici
ty and clinical data.