Ia. Kaltashov et al., ASSESSMENT OF GAS-PHASE BASICITIES OF PROTONATED PEPTIDES BY THE KINETIC METHOD, Journal of physical chemistry, 99(24), 1995, pp. 10046-10051
Gas phase basicities of protonated peptides can be obtained, based on
values of apparent basicities determined by a modified kinetic method,
and the reverse activation energy barrier due to Coulombic repulsion
can be determined by ion kinetic energy release spectrometry. The gas
phase basicity for protonated bradykinin has been determined to be 217
.8 +/- 1.7 kcal/mol. The value of the reverse activation energy barrie
r due to Coulombic repulsion has been determined by MIKES experiments
to be 13.6 +/- 1.4 kcal/mol. The influence of the distance between bas
ic residues in the peptide chain on Coulombic repulsion and gas phase
basicity was also investigated in a series of protonated isomeric pept
ides.