CHEMILUMINESCENCE IMMUNOASSAY - A REVIEW

Qualitative and quantitative analytical procedures that rely on the ph enomenon of chemiluminescence are now widely used in clinical biochemi stry, cell biology, and molecular biology. It is a little more than 15 years since the appearance of reports of immunoassays based on chemil uminescent signal detection. Since then, the inherent advantages of th ese non-isotopic labels have combined with other technological improve ments and sophisticated instrument development to provide immunoassays with a level of analytical performance that would have been difficult to imagine 15 years ago. This review highlights the main factors whic h I believe have contributed to this remarkable progress in high sensi tivity analysis.