Sh. Hahn et al., NORMAL METALLOTHIONEIN SYNTHESIS IN FIBROBLASTS OBTAINED FROM CHILDREN WITH INDIAN CHILDHOOD CIRRHOSIS OR COPPER-ASSOCIATED CHILDHOOD CIRRHOSIS, Biochemical and molecular medicine, 54(2), 1995, pp. 142-145
We previously demonstrated decreased metallothionein (MT) synthesis in
cultured fibroblasts obtained from an American boy with findings typi
cal of Indian Childhood Cirrhosis (ICC). We now report normal basal, c
opper-induced, and zinc-induced MT synthesis in the fibroblasts of two
Indian boys and one Irish boy with typical ICC and one Indian boy wit
h copper-associated childhood cirrhosis. This suggests that etiologies
other than impaired MT production should be sought as the primary def
ect in these disorders. (C) 1995 Academic Press, Inc.