USSING FLUX RATIO THEOREMS FOR ALBUMIN ENHANCED FATTY-ACID FLUXES ACROSS A LIPID-WATER INTERFACE

A system of transport equations is described for one dimensional diffu sion and interaction of ligand and protein in and across the boundarie s of four layers. This first two layers are aqueous solutions of ligan d, protein and ligand-protein complex, the outer, well stirred and the inner, unstirred. These exchange ligand with two layers of decane-lig and solution. An inner, unstirred decane solution abuts the unstirred aqueous solution and is bounded on the other side by a well stirred de cane layer. The system is nonlinear in the coupling, reaction terms an d computer solutions for the flux ratio, modelling the Weisiger experi ments, show the nonconstant behaviour of this ratio with time that suc h a nonlinearity might be expected to produce. An alternative, radiois otope experimental approach is suggested and analysed. It gives a line ar system of equations for the flux ratio experiments and a flux ratio value of one for all time, even for cases involving parameters with s patial and concentration dependence.