LACK OF REQUIREMENT FOR CD8(+) CELLS IN RECOVERY FROM AND RESISTANCE TO EXPERIMENTAL AUTOIMMUNE ENCEPHALOMYELITIS

Experimental autoimmune encephalomyelitis (EAE) is a model of T-cell m ediated autoimmune disease. Active disease is mediated by myelin basic protein specific CD4(+) T-cells, whose adoptive transfer can also ind uce passive disease. In the Lewis rat EAE is a transient disease induc ing lasting resistance to rechallenge. The mechanisms of recovery and resistance are poorly understood. CD8(+) suppressor T-cells have mostl y been thought to be central, especially in resistance to reinduction of the disease. In this study we showed by complete depletion of CD8() cells that this subset does not influence either recovery or resista nce to EAE in the Lewis rat. This was further confirmed by depleting C D8(+) cells only after recovery from acute EAE. Such depletion did not diminish the effective resistance to rechallenge. Recovery from and r esistance to EAE appear not to require the presence of CD8(+) cells.