CELL-MEDIATED AND HUMORAL IMMUNE-RESPONSES IN CHICKENS INFECTED WITH SALMONELLA-TYPHIMURIUM

Citation
M. Lessard et al., CELL-MEDIATED AND HUMORAL IMMUNE-RESPONSES IN CHICKENS INFECTED WITH SALMONELLA-TYPHIMURIUM, Avian diseases, 39(2), 1995, pp. 230-238
Citations number
39
Categorie Soggetti
Veterinary Sciences
Journal title
ISSN journal
00052086
Volume
39
Issue
2
Year of publication
1995
Pages
230 - 238
Database
ISI
SICI code
0005-2086(1995)39:2<230:CAHIIC>2.0.ZU;2-N
Abstract
The cellular immune responses of leghorn and New Hampshire chickens fo llowing oral challenge at 4 weeks of age with Salmonella typhimurium w ere measured using assays for lymphocyte proliferative responses to mi togens and cytotoxic activity of natural killer (NK) cells. In additio n, the humoral immune response to Newcastle disease virus (NDV) vaccin e was assessed in S. typhimurium-infected chickens. At 8 and 20 days a fter infection with S. typhimurium, lymphocyte proliferative responses to various mitogens were significantly higher in S. typhimurium-infec ted chickens than in uninfected birds of the same breeds. Cytotoxic ac tivity of NK cells was also significantly increased in infected birds on these days. Thirteen days after S. typhimurium infection, infected NDV vaccinated chickens had higher antibody titers in response to NDV vaccination than uninfected vaccinated birds. NDV titers did not diffe r among groups at any other time of testing. These results show that b oth cellular and humoral immune functions are activated in the first 3 weeks following infection of 4-week-old chickens with S. typhimurium.