TREATMENT OF HELICOBACTER-PYLORI INFECTION WITH A COMBINATION OF ITRACONAZOLE AND OMEPRAZOLE

Aim: To determine the in vivo anti-microbial activity of a high-dose i traconazole and omeprazole regimen against Helicobacter pylori. Method s: In an open pilot study, 10 H. pylori positive dyspeptic patients we re treated with itraconazole 200 mg b.d. and omeprazole 200 mg b.d. fo r 7 days. Follow-up upper gastrointestinal endoscopy was performed 4-5 weeks after completion of therapy. Eradication of H. pylori infection was determined by histopathological examination and culture of biopsi es from the antrum and corpus. Results: Eradication was not observed i n any patient. Conclusion: This combination of itraconazole with omepr azole does not eradicate H. pylori infection.