DECYCLOPROPYLATION OF CYCLOPROPYL-4-HYDROXY-4-(2-METHYLPHENYL)PIPERIDINE N-OXIDE

Authors
WANG YX CASTAGNOLI N
Citation
Yx. Wang et N. Castagnoli, DECYCLOPROPYLATION OF CYCLOPROPYL-4-HYDROXY-4-(2-METHYLPHENYL)PIPERIDINE N-OXIDE, Tetrahedron letters, 36(23), 1995, pp. 3981-3984
Citations number
12
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Tetrahedron letters → ACNP
ISSN journal
00404039
Volume
36
Issue
23
Year of publication
1995
Pages
3981 - 3984
Database
ISI
SICI code
0040-4039(1995)36:23<3981:DOC>2.0.ZU;2-P
Abstract
Treatment of cyclopropyl-4-hydroxy-4-(2-methylphenyl)piperidine N-oxid e with trifluoroacetic anhydride (TFAA) yields the corresponding descy clopropyl secondary amine in This reaction may serve as a model for th e mechanism based inactivation of monoamine oxidase B (MAO-B) by cyclo propylamines which recently has been proposed to proceed via a polar m echanism involving a flavin-amine adduct.