1,2-ASYMMETRIC INDUCTION IN RADICAL REACTIONS OF BETA-AMINO ACID-DERIVATIVES

Carbon centered radicals adjacent to a chiral amine and generated by t he addition of alkyl radicals to racemic or enantiomerically pure acry lates 1 react with tributyltin hydride in high yields and moderate to good diastereoselectivity. 1,2-Asymmetric induction depends on the nat ure of the groups at the stereogenic and the prochiral center and is r emarkably sensitive to changes in the aryl-o-substituent.