DIASTEREOSELECTIVE ALKYLATION OF SULTAM-DERIVED AMINO-ACID ALDIMINES PREPARATION OF C-ALPHA-METHYLATED AMINO-ACIDS

Authors
AYOUB M CHASSAING G LOFFET A LAVIELLE S
Citation
M. Ayoub et al., DIASTEREOSELECTIVE ALKYLATION OF SULTAM-DERIVED AMINO-ACID ALDIMINES PREPARATION OF C-ALPHA-METHYLATED AMINO-ACIDS, Tetrahedron letters, 36(23), 1995, pp. 4069-4072
Citations number
10
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Tetrahedron letters → ACNP
ISSN journal
00404039
Volume
36
Issue
23
Year of publication
1995
Pages
4069 - 4072
Database
ISI
SICI code
0040-4039(1995)36:23<4069:DAOSAA>2.0.ZU;2-H
Abstract
Alkylation of Schiff bases 2 derived from 4-chlorobenzaldehyde and sul tam-derived amino acids 1 gave crystalline diastereomers 3 which after deprotection and re-crystallization, if necessary, afforded in good y ield enantiomerically pure C alpha'-methylated amino acid (ex: alpha M ePhe, alpha MeLeu, alpha MeMet).