STEREOSELECTIVE SYNTHESIS OF NOVEL METHYLENE ETHER DIPEPTIDE ISOSTERES

Authors
NORMAN BH KROIN JS
Citation
Bh. Norman et Js. Kroin, STEREOSELECTIVE SYNTHESIS OF NOVEL METHYLENE ETHER DIPEPTIDE ISOSTERES, Tetrahedron letters, 36(24), 1995, pp. 4151-4154
Citations number
9
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Tetrahedron letters → ACNP
ISSN journal
00404039
Volume
36
Issue
24
Year of publication
1995
Pages
4151 - 4154
Database
ISI
SICI code
0040-4039(1995)36:24<4151:SSONME>2.0.ZU;2-K
Abstract
We have developed a versatile new synthesis of the Psi[CH2O] pseudopep tides from N-protected 5-substituted morpholin-3-ones. This approach f ocuses on a stereoselective alkylation of the morpholin-3-ones. The re sulting alkylation products were used in the synthesis of some previou sly unavailable Psi[CH2O] dipeptides.