CONVERGENT SYNTHESIS OF PYRROLIDINES, PIPERIDINES, PERHYDROAZEPINES AND TETRAHYDROISOQUINOLINES VIA ZIRCONOCENE ETA(2)-IMINE COMPLEXES

Authors
HARRIS MCJ WHITBY RJ BLAGG J
Citation
Mcj. Harris et al., CONVERGENT SYNTHESIS OF PYRROLIDINES, PIPERIDINES, PERHYDROAZEPINES AND TETRAHYDROISOQUINOLINES VIA ZIRCONOCENE ETA(2)-IMINE COMPLEXES, Tetrahedron letters, 36(24), 1995, pp. 4287-4290
Citations number
12
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Tetrahedron letters → ACNP
ISSN journal
00404039
Volume
36
Issue
24
Year of publication
1995
Pages
4287 - 4290
Database
ISI
SICI code
0040-4039(1995)36:24<4287:CSOPPP>2.0.ZU;2-F
Abstract
Zirconocene eta(2)-imine complexes formed by a C-H activation route fr om a variety of amines are trapped by omega-halo-alkenes or -alkynes t o afford 2,3-disubstituited pyrrolidines, piperidines and perhydroazep ines on work up and cyclisation. In some cases ii was necessary to use a protected hydroxyl group rather than the halide and cyclise in a se parate step through selective formation of the O-mesylate.