Cll. Chai et Ar. King, METHYLENE PIPERAZINE-2,5-DIONES AS TEMPLATES FOR THE SYNTHESIS OF AMINO-ACID DERIVATIVES, Tetrahedron letters, 36(24), 1995, pp. 4295-4298
Methylene piperazine-2,5-diones 5a and 5b are important synthetic inte
rmediates. The preparation as well as the use of these compounds in th
e synthesis of amino acid derivatives are described. Our studies demon
strate that excellent chiral induction in carbon-carbon bond forming r
eactions can be obtained with methylene piperazinedione 5b.