G. Turecki et al., TYPE-I BIPOLAR DISORDER ASSOCIATED WITH A FRAGILE SITE ON CHROMOSOME-1, American journal of medical genetics, 60(3), 1995, pp. 179-182
The objective of this paper is to study the association between chromo
somal fragile sites and type I bipolar disorder, This case-control stu
dy compares bipolar patients with normal controls, Ten cases of type I
bipolar disorder diagnosed according to DSM-III-R criteria and the Co
mposite International Diagnostic Interview (CIDI) were selected from t
he Escola Paulista affective disorders outpatient clinic and 10 health
y controls (CIDI negative for psychiatric diagnoses) matched for sex a
nd age were drawn from the otorhinolaryngologic outpatient clinic of t
he same hospital, The cytogenetic analysis was carried out with blood
lymphocytes, which were cultured in a folic acid-free medium. A total
of 100 mitoses per subject were blindly analyzed to the psychiatric di
agnostic assignment, and fragile sites were identified according to a
minimum expected frequency of events per band in conformity with a Poi
sson distribution. A higher frequency of chromosomal lesions for cases
than controls was found for the following bands: 1q32, 5q31, and 11q2
3, the 1q32 being considered a fragile site. Although no evident neuro
psychiatric etiological component has been mapped to the 1q32 region s
o far, this finding may lead to further investigation of a possible li
nkage between genetic markers of this region and bipolar disorder, (C)
1995 Wiley-Liss, Inc.