A PNA-DNA LINKER SYNTHESIS OF THOXYTRITYLOXY)ETHYL)-N-(THYMIN-1-YLACETYL)GLYCINE

Authors
PETERSEN KH JENSEN DK EGHOLM M NIELSEN PE BUCHARDT O
Citation
Kh. Petersen et al., A PNA-DNA LINKER SYNTHESIS OF THOXYTRITYLOXY)ETHYL)-N-(THYMIN-1-YLACETYL)GLYCINE, Bioorganic & medicinal chemistry letters, 5(11), 1995, pp. 1119-1124
Citations number
10
Categorie Soggetti
Chemistry Inorganic & Nuclear","Chemistry Medicinal
Journal title
Bioorganic & medicinal chemistry letters → ACNP
ISSN journal
0960894X
Volume
5
Issue
11
Year of publication
1995
Pages
1119 - 1124
Database
ISI
SICI code
0960-894X(1995)5:11<1119:APLSOT>2.0.ZU;2-B
Abstract
N-(2-benzyloxyethyl)-N-(thymin-1-ylacetyl)glycine was synthesised and used as a linker for coupling DNA and PNA together. Three different 10 -mers composed of 6 DNA units and 4 PNA thymine units were made. The P NA-DNA chimera hybridise to complementary DNA or PNA oligomers, and bo th the PNA and the DNA part of the chimera are involved in the binding .