A MEDICINAL CHEMISTRY EVALUATION OF THE AUTOINHIBITORY DOMAIN OF CALCINEURIN

Authors
RIVETNA MN SALOWE SP TOLMAN RL JONES AB
Citation
Mn. Rivetna et al., A MEDICINAL CHEMISTRY EVALUATION OF THE AUTOINHIBITORY DOMAIN OF CALCINEURIN, Bioorganic & medicinal chemistry letters, 5(11), 1995, pp. 1147-1150
Citations number
14
Categorie Soggetti
Chemistry Inorganic & Nuclear","Chemistry Medicinal
Journal title
Bioorganic & medicinal chemistry letters → ACNP
ISSN journal
0960894X
Volume
5
Issue
11
Year of publication
1995
Pages
1147 - 1150
Database
ISI
SICI code
0960-894X(1995)5:11<1147:AMCEOT>2.0.ZU;2-R
Abstract
Truncation of and substitutions in, the 25 amino acid autoinhibitory e lement of the phosphatase calcineurin indicate that most of the segmen t is required for inhibition. The peptide does not, therefore, represe nt a convenient starting point for small molecule drug development.