SYNTHESIS OF PEPTIDE NUCLEIC-ACIDS (PNA) BY SUBMONOMER SOLID-PHASE SYNTHESIS

Authors
RICHTER LS ZUCKERMANN RN
Citation
Ls. Richter et Rn. Zuckermann, SYNTHESIS OF PEPTIDE NUCLEIC-ACIDS (PNA) BY SUBMONOMER SOLID-PHASE SYNTHESIS, Bioorganic & medicinal chemistry letters, 5(11), 1995, pp. 1159-1162
Citations number
12
Categorie Soggetti
Chemistry Inorganic & Nuclear","Chemistry Medicinal
Journal title
Bioorganic & medicinal chemistry letters → ACNP
ISSN journal
0960894X
Volume
5
Issue
11
Year of publication
1995
Pages
1159 - 1162
Database
ISI
SICI code
0960-894X(1995)5:11<1159:SOPN(B>2.0.ZU;2-0
Abstract
A simple, versatile method for the synthesis of Peptide Nucleic Acids (PNA) from readily available building blocks has been developed. The a pproach is based on submonomer solid phase synthesis and allows for th e structural variation of both the backbone and the nucleobase sidecha in. The efficiency of the method was demonstrated by the synthesis of PNA oligomers in high purity and good yields.