THE EFFECT OF PYRROLO[3,4-C] CARBAZOLE DERIVATIVES ON SPINAL-CORD CHAT ACTIVITY

Authors
ROTELLA DP GLICKSMAN MA PRANTNER JE NEFF NT HUDKINS RL
Citation
Dp. Rotella et al., THE EFFECT OF PYRROLO[3,4-C] CARBAZOLE DERIVATIVES ON SPINAL-CORD CHAT ACTIVITY, Bioorganic & medicinal chemistry letters, 5(11), 1995, pp. 1167-1170
Citations number
17
Categorie Soggetti
Chemistry Inorganic & Nuclear","Chemistry Medicinal
Journal title
Bioorganic & medicinal chemistry letters → ACNP
ISSN journal
0960894X
Volume
5
Issue
11
Year of publication
1995
Pages
1167 - 1170
Database
ISI
SICI code
0960-894X(1995)5:11<1167:TEOPCD>2.0.ZU;2-4
Abstract
Pyrrolo[3,4-c]carbazole derivatives were prepared as potential neurotr ophic agents. The compounds were assayed for their ability to stimulat e choline acetyltransferase (ChAT) activity in embryonic rat spinal co rd cultures. These simplified K252a derivatives, although less potent and efficacious, have led to the identification of minimal structural requirements for K252a neurotrophic activity.