2,4,5-TRIARYLIMIDAZOLE INHIBITORS OF IL-1 BIOSYNTHESIS

Authors
GALLAGHER TF FIERTHOMPSON SM GARIGIPATI RS SORENSON ME SMIETANA JM LEE D BENDER PE LEE JC LAYDON JT GRISWOLD DE CHABOTFLETCHER MC BRETON JJ ADAMS JL
Citation
Tf. Gallagher et al., 2,4,5-TRIARYLIMIDAZOLE INHIBITORS OF IL-1 BIOSYNTHESIS, Bioorganic & medicinal chemistry letters, 5(11), 1995, pp. 1171-1176
Citations number
26
Categorie Soggetti
Chemistry Inorganic & Nuclear","Chemistry Medicinal
Journal title
Bioorganic & medicinal chemistry letters → ACNP
ISSN journal
0960894X
Volume
5
Issue
11
Year of publication
1995
Pages
1171 - 1176
Database
ISI
SICI code
0960-894X(1995)5:11<1171:2IOIB>2.0.ZU;2-E
Abstract
As part of an effort to define the pharmacophore and discover the mech anism by which the anti-inflammatory dual cyclooxygenase / 5-lipoxygen ase inhibitors SK & F 86002 and SK & F 105809 inhibit IL-1 biosynthesi s, a series of substituted 2,4,5-triarylimidazole derivatives were pre pared and evaluated as inhibitors of IL-1 and 5-lipoxygenase biosynthe sis.