THE TYROSINE KINASE INHIBITOR METHYL 2,5-DIHYDROXYCINNIMATE DISRUPTS CHANGES IN THE ACTIN CYTOSKELETON REQUIRED FOR NEURITE FORMATION

Authors
LEVENTHAL PS FELDMAN EL
Citation
Ps. Leventhal et El. Feldman, THE TYROSINE KINASE INHIBITOR METHYL 2,5-DIHYDROXYCINNIMATE DISRUPTS CHANGES IN THE ACTIN CYTOSKELETON REQUIRED FOR NEURITE FORMATION, Molecular brain research, 43(1-2), 1996, pp. 338-340
Citations number
17
Categorie Soggetti
Neurosciences
Journal title
Molecular brain research → ACNP
ISSN journal
0169328X
Volume
43
Issue
1-2
Year of publication
1996
Pages
338 - 340
Database
ISI
SICI code
0169-328X(1996)43:1-2<338:TTKIM2>2.0.ZU;2-N
Abstract
In the current studies, we investigated the relationship between tyros ine phosphorylation and neurite formation. In SH-SY5Y neuroblastoma ce lls, the tyrosine kinase inhibitor methyl 2,5-dihydroxycinnimate block ed neurite formation on laminin. This corresponded with inhibition of paxillin and focal adhesion kinase tyrosine phosphorylation as well as a disruption of actin filament organization and actin polymerization. This suggests that tyrosine phosphorylation helps direct changes in t he actin cytoskeleton required for neurite formation.