Ps. Leventhal et El. Feldman, THE TYROSINE KINASE INHIBITOR METHYL 2,5-DIHYDROXYCINNIMATE DISRUPTS CHANGES IN THE ACTIN CYTOSKELETON REQUIRED FOR NEURITE FORMATION, Molecular brain research, 43(1-2), 1996, pp. 338-340
In the current studies, we investigated the relationship between tyros
ine phosphorylation and neurite formation. In SH-SY5Y neuroblastoma ce
lls, the tyrosine kinase inhibitor methyl 2,5-dihydroxycinnimate block
ed neurite formation on laminin. This corresponded with inhibition of
paxillin and focal adhesion kinase tyrosine phosphorylation as well as
a disruption of actin filament organization and actin polymerization.
This suggests that tyrosine phosphorylation helps direct changes in t
he actin cytoskeleton required for neurite formation.