THE ROLE OF DOPAMINE IN PSYCHOTIC DEPRESSION

Major depression with psychotic features (PMD) represents a distinct a nd severe subtype of depression. This article reviews characteristics that distinguish PMD from nonpsychotic major depression. Emphasis is p laced on increased activity of the hypothalamic-pituitary-adrenal axis and dopamine systems in PMD. Interactions between the two systems are reviewed as a means for understanding the biological basis for psycho tic thinking in depressed patients. Strategies for addressing key rese arch questions in this area are discussed.