SYSTEMIC ADMINISTRATION OF GM1 GANGLIOSIDE INCREASES CHOLINE-ACETYLTRANSFERASE ACTIVITY IN THE BRAIN OF AGED RATS

Authors
FONG TG NEFF NH HADJICONSTANTINOU M
Citation
Tg. Fong et al., SYSTEMIC ADMINISTRATION OF GM1 GANGLIOSIDE INCREASES CHOLINE-ACETYLTRANSFERASE ACTIVITY IN THE BRAIN OF AGED RATS, Experimental neurology, 132(2), 1995, pp. 157-161
Citations number
46
Categorie Soggetti
Neurosciences
Journal title
Experimental neurology → ACNP
ISSN journal
00144886
Volume
132
Issue
2
Year of publication
1995
Pages
157 - 161
Database
ISI
SICI code
0014-4886(1995)132:2<157:SAOGGI>2.0.ZU;2-L
Abstract
In the brain of aged rats (22-24 months old) choline acetyltransferase (ChAT) activity in striatum and frontal cortex is lower than in young rats (4-5 months old). In contrast, ChAT activity in the hippocampus is similar in the two groups. Treating old animals with GM1 gangliosid e, 30 mg/kg ip, for 30 or 45 days enhances ChAT activity in the striat um and frontal cortex, but has no effect on activity in the hippocampu s. ChAT activity remains elevated in the striatum and frontal cortex f or 15 days after discontinuing treatment with GM1. (C) 1995 Academic P ress, Inc.