THE EFFECTS OF ANORECTIC AND AVERSIVE AGENTS ON DEPRIVATION-INDUCED FEEDING AND TASTE-AVERSION CONDITIONING IN RATS

We compared the effects of intraperitoneally administered LiCl (0.5-28 30 mu mol/kg), sulfated cholecystokinin(26-33) (10-1000 nmol/kg; CCK-8 ), nonsulfated CCK-8 (500 and 1000 nmol/kg), sulfated CCK26-29 (500 an d 1000 nmol/kg), CCK30-33 (10-1000 nmol/kg), bombesin (10-1000 nmol/kg ; BOM), (dl)-fenfluramine HCl (0.9-37.3 mu mol/kg; fenfluramine), fluo xetine HCl (2.9-86.7 mu mol/kg; fluoxetine), and d-amphetamine sulfate (0.27-10.9 mu mol/kg; AMPH) on both 18-hr deprivation-induced feeding and one-bottle, taste aversion conditioning in male, Long-Evans rats. Doses of LiCl greater than or equal to 177 mu mol/kg (or 7.5 mg/kg) i nduced significant, dose-related taste aversions, but only doses of Li Cl greater than or equal to 2123 mu mol/kg (90 and 120 mg/kg) induced significant anorexia. CCK-8 induced marked anorexia (at doses greater than or equal to 25-50 nmol/kg), but only relatively mild taste aversi ons which were only statistically significant at the highest dose (100 0 nmol/kg). The anorectic effects of CCK-8 at 500 and 1000 nmol/kg, bu t not at lower doses, lasted at least 3 hr. Sulfated CCK26-29, CCK30-3 3 and nonsulfated CCK-8 induced neither anorexia nor taste aversion. B OM induced marked anorexia at all doses tested, but did not induce sta tistically significant taste aversions. The nonpeptidal anorectic comp ounds, fenfluramine, fluoxetine, and AMPH, induced both dose-related a norexia and taste aversion conditioning. We focus on several issues co ncerning the interpretation of taste aversion conditioning. Our result s challenge any simple relationship between the ability of a compound to induce taste aversion and to decrease feeding.