EVOLUTION OF SUSCEPTIBILITY OF PENICILLIN -G OF STREPTOCOCCUS-PNEUMONIA AT LIMOGES HOSPITAL

A systematic detection of Streptococcus pneumoniae strains with reduce d susceptibility to penicillin has been realized at Limoges Hospital d uring two years half. Of 302 strains isolated 27 had reduced susceptib ility to penicillin (8,9%), and, for 15 strains (5%), the MIC of penic illin G reached at least 2 mg/l. The frequency of strains with reduced susceptibility to penicillin increased from 1992 to 1994: 8,2% in 199 2, 8,7% in 1993 and 12,2% in 1994. The resistance level exhibited by p neumococcus strains increased Since 1992: the percentage of resistant strains (MIG mg/l > 1) was 2,7% in 1992, 6,9% in 1993 and 7,3% in 1994 . Most of the strains with reduced susceptibility to penicillin belong ed to serotype 23 (52%) and were isolated from blood cultures, cerebra l-spinal or pleural fluids (41%).