2 FETAL HEMOGLOBIN-VARIANTS AFFECTING THE SAME RESIDUE - HB F-EMIRATES [(G)GAMMA-59(E3)LYS-]GLU] AND HB F-SACROMONTE [(G)GAMMA-59(E3)LYS-]GLN]

Authors
ABBES S FITZGERALD PA VARADY E GIROT R PIC P BLOUQUIT Y DUCROCQ R DRUPT F WAJCMAN H
Citation
S. Abbes et al., 2 FETAL HEMOGLOBIN-VARIANTS AFFECTING THE SAME RESIDUE - HB F-EMIRATES [(G)GAMMA-59(E3)LYS-]GLU] AND HB F-SACROMONTE [(G)GAMMA-59(E3)LYS-]GLN], Hemoglobin, 19(3-4), 1995, pp. 173-182
Citations number
11
Categorie Soggetti
Biology,Hematology
Journal title
Hemoglobin → ACNP
ISSN journal
03630269
Volume
19
Issue
3-4
Year of publication
1995
Pages
173 - 182
Database
ISI
SICI code
0363-0269(1995)19:3-4<173:2FHATS>2.0.ZU;2-8
Abstract
Two fast-moving fetal hemoglobin variants were discovered in hematolog ically normal newborn babies; the first originated in the United Arab Emirates and the second in France. The structural study, carried out b y miniaturized techniques of protein chemistry, showed that these two mutations affected the same residue of the (G) gamma chain, the lysine at position 59(E3) was replaced by glutamic acid in Hb F-Emirates, an d by glutamine in Hb F-Sacromonte.