SUCCESSFUL TREATMENT OF PRIMARY SCLEROSING CHOLANGITIS WITH CYCLOSPORINE AND CORTICOSTEROID

A case of primary sclerosing cholangitis (PSC) successfully treated wi th cyclosporine is described. A 65-year-old man who presented with jau ndice and anemia was diagnosed as having PSC, accompanied by pancreati c duct abnormalities. Cholangiography and pancreatography showed marke d improvements following combined therapy with cyclosporine and methyl prednisolone. Cyclosporine seems to be a promising drug for the treatm ent of patients with PSC. This report reasons that the same disease pr ocess affects both the pancreatic ducts and the bile ducts, and that s tagnation of pancreatic juice may have a role to play in the pancreati c duct abnormalities.