SIMULATING THE PROCESS OF MALIGNANT TRANSFORMATION

Authors
LUEBECK EG MOOLGAVKAR SH
Citation
Eg. Luebeck et Sh. Moolgavkar, SIMULATING THE PROCESS OF MALIGNANT TRANSFORMATION, Mathematical biosciences, 123(2), 1994, pp. 127-146
Citations number
27
Categorie Soggetti
Mathematical Methods, Biology & Medicine","Mathematics, Miscellaneous","Biology Miscellaneous
Journal title
Mathematical biosciences → ACNP
ISSN journal
00255564
Volume
123
Issue
2
Year of publication
1994
Pages
127 - 146
Database
ISI
SICI code
0025-5564(1994)123:2<127:STPOMT>2.0.ZU;2-Z
Abstract
A computationally efficient method for the simulation of carcinogenesi s is presented. The underlying model for the process is the two-mutati on clonal expansion model with explicit consideration of stochastic gr owth of malignant tumors. The usual likelihood-based methods of analys is ignore the growth kinetics of malignant tumors. The effect of this oversight on estimation of parameters is explored by simulation.