Genetic mechanisms in bacteria provide a continuous source of alterati
ons in DNA sequences that may lead to favourable adaptations. Bacteria
that use chlorinated aromatics as sole carbon and energy sources show
evidence of these different genetic alterations. The distinct effects
of single base-pair mutations on adaptation of bacterial strains (e.g
. by changing the substrate specificity of a key metabolic enzyme or r
egulator protein) have been demonstrated in various studies. In additi
on to these small sequence modifications, intermolecular or intercellu
lar gene exchange mechanisms can result in new strains with altered me
tabolic capabilities. The details of these evolutionary processes with
respect to the metabolism of chlorobenzenes and chlorocatechols are r
eviewed in this manuscript.